Why should you book Myrtle Beach, SC to Tampa, FL buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Southeastern Stages to find the best option for your trip from Myrtle Beach, SC to Tampa, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Myrtle Beach, SC to Tampa, FL
Buses from Myrtle Beach, SC to Tampa, FL run on average 3 times per day, taking around 12h 10m. Cheap bus tickets for this journey start at $277 (€225) if you book in advance.
The earliest bus runs at 06:10, the last at 22:35. The fastest bus covers the 449 miles (724 km) distance in 36h 20m.
Distance 449 miles (724 km) |
Average bus duration 12h 10m |
Cheapest ticket price $277 (€225) |
Buses per day 3 |
Fastest bus 36h 20m |
First bus 6:10 AM |
Last bus 10:35 PM |
Bus providers: FlixBus, Southeastern Stages from Myrtle Beach, SC to Tampa, FLYou can travel by bus between Myrtle Beach, SC to Tampa, FL with FlixBus, Southeastern Stages for as low as $277 (€225). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Southeastern Stages
FAQs: Bus from Myrtle Beach, SC to Tampa, FL
Find answers to the most common questions about traveling from Myrtle Beach, SC to Tampa, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Tampa, FL, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Busch Gardens Tampa Bay, a renowned theme park offering thrilling rides and animal encounters
- The Florida Aquarium, a popular attraction featuring marine life exhibits and interactive experiences
- Tampa Riverwalk, a scenic waterfront path with parks, museums, and dining options
- Ybor City, a historic district known for its vibrant nightlife and Cuban culture
- Tampa Museum of Art, showcasing contemporary and classical art in a modern architectural setting.
- Visit the historic Henry B. Plant Museum, housed in a former luxury hotel with exhibits on the Gilded Age
- Explore the vibrant Hyde Park Village, offering shopping, dining, and entertainment
- Attend a Tampa Bay Buccaneers game at Raymond James Stadium for an exciting sports experience
- Take a boat tour of Tampa Bay for stunning views and wildlife sightings
- Enjoy a day at the beautiful Clearwater Beach, just a short drive from Tampa.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Myrtle Beach, SC to Tampa, FL
Most popular bus connections from Myrtle Beach, SC
More options for your journey from Myrtle Beach, SC to Tampa, FL
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