Journey information
Overview: Bus from Orlando, FL to Knoxville, TN
Take a bus from Orlando, FL to Knoxville, TN and enjoy the approximately 533 miles (859 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 05:15, the last at 22:55.
Distance 533 miles (859 km) |
Average bus duration 24h 25m |
Buses per day 3 |
First bus 05:15 |
Last bus 22:55 |
Bus providers: FlixBus from Orlando, FL to Knoxville, TNYou can travel by bus between Orlando, FL to Knoxville, TN with FlixBus. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Orlando, FL to Knoxville, TN
Find answers to the most common questions about traveling from Orlando, FL to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
To find the cheapest bus tickets for your trip from Orlando, FL to Knoxville, TN, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
popular bus stations
Popular bus stations from Orlando, FL to Knoxville, TN
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Knoxville, TN
Here are some other resources that might have the information you need
