Travel Information
Compare bus and train for San Luis Obispo, CA to Santa Clara, CA
Omio recommends booking the train as it is the most popular option from San Luis Obispo, CA to Santa Clara, CA among Omio's users. If you are prioritising price take the bus with prices starting from $71. For those with little time consider booking a bus which can get you there in 4h 8m. The ticket price range depends on the travel mode: a bus costs an average of $71, and a train costs an average of $112.
Distance: 160 miles (258 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
$72 Average price Cheapest | $115 Average price |
4h 38m Average total duration Fastest 4h 8m Onboard + 30m Additional time* | 11h 24m Average total duration 10h 54m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
San Luis Obispo, CA to Santa Clara, CA bus times
The table below shows live departures for San Luis Obispo, CA to Santa Clara, CA buses for today, Friday, April 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:55 PM San Luis Obispo, CA | 5h15 | 2:10 AM Santa Clara, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Luis Obispo, CA to Santa Clara, CA by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from San Luis Obispo, CA to Santa Clara, CA
Buses from San Luis Obispo, CA to Santa Clara, CA run on average 8 times per day, taking around 4h 8m. Cheap bus tickets for this journey start at $71 (€57) if you book in advance.
The earliest bus runs at 00:30, the last at 14:55. The fastest bus covers the 160 miles (258 km) distance in 4h 27m.
Distance 160 miles (258 km) |
Average bus duration 4h 8m |
Cheapest ticket price $71 (€57) |
Buses per day 8 |
Fastest bus 4h 27m |
First bus 12:30 AM |
Last bus 2:55 PM |
FAQs: Bus from San Luis Obispo, CA to Santa Clara, CA
Find answers to the most common questions about traveling from San Luis Obispo, CA to Santa Clara, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Clara, CA, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from San Luis Obispo, CA to Santa Clara, CA
Most popular bus connections from San Luis Obispo, CA
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