2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Siena to Brindisi
Showing times and prices for Apr 02
Cheapest price
$55
Average price
$110
Fastest journey
8 h
Average duration
10 h 14 m
Buses per day
9
Distance
622 km
Cheap tickets
The best way to find a cheap bus ticket from Siena to Brindisi is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Siena to Brindisi will cost around $110 if you buy it on the day, but the cheapest tickets can be found for only $55.
Fast buses
Of the 9 buses that leave Siena for Brindisi on Thu, Apr 02, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Apr 02 the direct buses cover the 622 km distance in an average of 10 h 14 m but if you time it right, some buses will get you there in just 8 h .
On Thu, Apr 02 the slowest buses will take 11 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3:00 PM8h00Siena11:00 PMBrindisi$551One-way0 transfers- 8:10 AM8h30Siena4:40 PMBrindisi$771One-way0 transfers
11219:25 AM11h00Siena, Stazione FS (Piazzale Carlo Rosselli)8:25 PMBrindisi, Via Giuseppe Maria Galanti (Istituto Professionale)$811One-way0 transfers
FlixBus · FlixBus5:35 AM14h10Siena, Stazione FS (Piazzale Carlo Rosselli)7:45 PMBrindisi, Via Giuseppe Maria Galanti (Istituto Professionale)$1101One-way1 transfer- FlixBus · FlixBus · FlixBus10:25 PM15h30Siena, Stazione FS (Piazzale Carlo Rosselli)1:55 PMBrindisi, Via Giuseppe Maria Galanti (Istituto Professionale)$1151One-way2 transfers
- 3:00 PM8h00Siena11:00 PMBrindisi$551One-way0 transfers
- 8:10 AM8h30Siena4:40 PMBrindisi$771One-way0 transfers
- 11219:25 AM11h00Siena, Stazione FS (Piazzale Carlo Rosselli)8:25 PMBrindisi, Via Giuseppe Maria Galanti (Istituto Professionale)$811One-way0 transfers
- FlixBus · FlixBus6:25 PM11h45Siena, Stazione FS (Piazzale Carlo Rosselli)6:10 AMBrindisi, Via Giuseppe Maria Galanti (Istituto Professionale)$1311One-way1 transfer
1088:30 PM11h55Siena, Stazione FS (Piazzale Carlo Rosselli)8:25 AMBrindisi, Via Giuseppe Maria Galanti (Istituto Professionale)$1191One-way0 transfers
Travel Information
Compare train, bus, and flight for Siena to Brindisi
Omio recommends booking the bus as it is the most popular option from Siena to Brindisi among Omio's users. If you are prioritising price take the bus with prices starting from $24. For those with little time consider booking a flight which can get you there in 1h 30m. The ticket price range depends on the travel mode: a bus costs an average of $24, and a flight costs an average of $24.
Distance: 386 miles (622 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
$57 Average price Cheapest | $161 Average price | $108 Average price |
11h 27m Average total duration 10h 57m Onboard + 30m Additional time* | 4h 30m Average total duration Fastest 1h 30m Onboard + 3h 0m Additional time* | 8h 52m Average total duration 8h 22m Onboard + 30m Additional time* |
Most popular bus company |  Most popular airline |  Most popular train company |
Direct Options | Direct Options | Direct Options |
Siena to Brindisi Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:45AM | Arrival Time 04:40PM | Duration 15h55 | Departure days Mon | Cheapest price $107 |
Operator FlixBus | Departure Time 05:35AM | Arrival Time 07:45PM | Duration 14h10 | Departure days Mon, Thu | Cheapest price $110 |
Operator FlixBus | Departure Time 06:50AM | Arrival Time 10:10PM | Duration 15h20 | Departure days Mon | Cheapest price $76 |
Operator FlixBus | Departure Time 07:00AM | Arrival Time 10:10PM | Duration 15h10 | Departure days Mon | Cheapest price $76 |
Operator FlixBus | Departure Time 07:10AM | Arrival Time 10:10PM | Duration 15h00 | Departure days Mon | Cheapest price $76 |
Operator BlaBlaCar | Departure Time 08:10AM | Arrival Time 04:40PM | Duration 8h30 | Departure days Thu | Cheapest price $77 |
Operator Itabus | Departure Time 09:25AM | Arrival Time 08:25PM | Duration 11h00 | Departure days Thu | Cheapest price $81 |
Operator FlixBus | Departure Time 02:51PM | Arrival Time 07:15AM | Duration 16h24 | Departure days Mon, Thu | Cheapest price $111 |
Operator BlaBlaCar | Departure Time 03:00PM | Arrival Time 11:00PM | Duration 8h00 | Departure days Thu | Cheapest price $55 |
Operator FlixBus | Departure Time 06:25PM | Arrival Time 06:10AM | Duration 11h45 | Departure days Mon, Thu | Cheapest price $131 |
Operator FlixBus | Departure Time 06:40PM | Arrival Time 10:05AM | Duration 15h25 | Departure days Thu | Cheapest price $154 |
Operator Marino Autolinee | Departure Time 07:30PM | Arrival Time 08:25AM | Duration 12h55 | Departure days Mon | Cheapest price $109 |
Operator Marino Autolinee | Departure Time 08:30PM | Arrival Time 08:25AM | Duration 11h55 | Departure days Thu | Cheapest price $119 |
Operator FlixBus | Departure Time 10:25PM | Arrival Time 01:55PM | Duration 15h30 | Departure days Mon, Thu | Cheapest price $115 |
Live departures
Siena to Brindisi bus times
The table below shows live departures for Siena to Brindisi buses for today, Wednesday, April 1. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 10:05 AM Siena | 11h05 | 9:10 PM Brindisi | 0 transfersDirect | |
| 5:50 PM Siena | 12h40 | 6:30 AM Brindisi | 0 transfersDirect | |
| 7:30 PM Siena | 11h55 | 7:25 AM Brindisi | 0 transfersDirect | |
| Thursday, April 2 | |||||
| FlixBus · FlixBus | 3:35 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 14h10 | 5:45 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Siena to Brindisi by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Thu
Apr 02
Apr 02
Fri
Apr 03
Apr 03
Sat
Apr 04
Apr 04
Sun
Apr 05
Apr 05
Mon
Apr 06
Apr 06
Tue
Apr 07
Apr 07
Wed
Apr 08
Apr 08
Why should you book Siena to Brindisi buses with Omio?
Marino Autolinee as well as Itabus or FlixBus offer buses services from Siena to Brindisi.
Omio is an official ticket reseller for all your travel options from Siena to Brindisi.
Why book with Omio vs Marino Autolinee?
- Compare with other providers: On Omio, you can not only buy tickets for Marino Autolinee, but also compare tickets for the likes of Itabus or FlixBus to find the best option for your trip from Siena to Brindisi.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Marino Autolinee with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Siena to Brindisi.
Why book with Omio over Checkmybus, Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus or FlixBus to find the best option for your trip from Siena to Brindisi.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Siena to Brindisi.
Journey information
Overview: Bus from Siena to Brindisi
ItalyItaly
Buses from Siena to Brindisi run on average 14 times per day, taking around 10h 57m. Cheap bus tickets for this journey start at $24 (€19) but you can travel from only $24 (€19) by flight.
There are 2 buses per day. The earliest bus runs at 00:05, the last at 23:39. The fastest bus covers the 386 miles (622 km) distance in 10h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $24 (€19)
Distance 386 miles (622 km) |
Average bus duration 10h 57m |
Cheapest ticket price $24 (€19) |
Buses per day 14 |
Direct buses 2 |
Fastest bus 10h 40m |
First bus 12:05 AM |
Last bus 11:39 PM |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $24 (€19)
Bus providers: Marino Autolinee, Itabus, FlixBus from Siena to BrindisiYou can travel by bus between Siena to Brindisi with Marino Autolinee, Itabus, FlixBus for as low as $24 (€19). When you search for schedules and tickets, Omio will show you the best journey
Marino Autolinee
About
MarinoBus is an Italian bus company with more than 200 destinations and 6,000 connections across Italy and Europe. Originally focused on Basilicata and Apulia, its network has expanded to cover the rest of Italy as well as Switzerland, France, Germany, and Luxembourg. All MarinoBus coaches are equipped with spacious reclining seats, air conditioning, onboard restrooms, WiFi, minibars, and color TVs. For your next trip, you can book the standard ticket, which includes one piece of hand luggage and up to two checked bags per passenger
Luggage & cancellation policy
Average Duration
11h 5m
Cheapest Price
$63 (€51)
Marino Autolinee frequency
3 a day
Luggage included
One carry-on bag up to 10kg (55x40x20 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
10€ per additional bag up to 20 kg.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a full refund. Cancellations within 24 hours incur a 50% fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Accessible restrooms.
Bikes
Bikes are allowed.
Pets
Small pets allowed in carriers; larger pets must be leashed and muzzled.
Itabus
About
Itabus is a leading bus company in Italy, providing reliable and comfortable transportation services to its customers. Itabus operates a fleet of modern buses, ranging from luxury coaches to standard buses, all equipped with air conditioning, comfortable seating, and onboard entertainment.
Luggage & cancellation policy
Average Duration
10h 40m
Cheapest Price
$24 (€19)
Itabus frequency
1 a day
Luggage included
One carry-on bag up to 10kg and one checked bag up to 20kg.
Additional luggage
5€ per additional bag.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Dedicated seating areas; Accessible restrooms.
Bikes
Bikes are allowed.
Pets
Small pets allowed in carriers; larger pets must be leashed and muzzled.
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
11h 45m
Cheapest Price
$49 (€40)
FlixBus frequency
3 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
FAQs: Bus from Siena to Brindisi
Find answers to the most common questions about traveling from Siena to Brindisi by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brindisi, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Siena to Brindisi can start from as little as $24 (€19) when you book in advance. The average bus ticket price for Siena to Brindisi is $57 (€47) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Siena to Brindisi is 10h 40m to travel the 386 miles (622 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Siena to Brindisi leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Siena to Brindisi leaves at 11:39 PM.
Yes, there are 2 direct buses a day from Siena to Brindisi with Marino Autolinee. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Siena to Brindisi, you can count on Marino Autolinee, Itabus, FlixBus for the best way to get you to Brindisi. You can also check all possible bus companies who offer a service between Siena and Brindisi and compare the amenities they offer before buying a bus ticket.
A trip to Brindisi from Siena is worth doing but not as a day trip with a journey time of 10h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Siena to Brindisi is January.
It's helpful to compare your options as there are 3 ways to travel between Siena and Brindisi including taking a train, bus, and flight.
Yes, there are bathrooms on board the bus from Siena to Brindisi for bus company Marino Autolinee, Itabus, FlixBus.
Yes, the following accessibility options are available when taking the bus from Siena to Brindisi:
- Marino Autolinee
- Assistance
- Priority seating
- Accessible restrooms.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
Whether you can cancel your bus ticket from Siena to Brindisi depends on the bus companies:
- Marino Autolinee
- You can cancel your ticket up to 24 hours before departure for a full refund. Cancellations within 24 hours incur a 50% fee.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
Yes, bikes are allowed on board the bus with bus company Marino Autolinee, Itabus, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Siena to Brindisi.
Yes, the following luggage options are included when booking a bus ticket from Siena to Brindisi:
- Marino Autolinee
- One carry-on bag up to 10kg (55x40x20 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
Yes, the following additional luggage options are available when booking a bus ticket from Siena to Brindisi:
- Marino Autolinee
- 10€ per additional bag up to 20 kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
Yes, you can bring your pet on the bus from Siena to Brindisi. The following conditions apply:
- Marino Autolinee
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
You can reserve your seat on the bus from Siena to Brindisi with the following bus company: Marino Autolinee, Itabus, FlixBus
Yes, there are USB plugs on board the bus from Siena to Brindisi with the following bus company: Marino Autolinee, Itabus, FlixBus.
Yes, there is Wifi on board the bus from Siena to Brindisi with the following bus company: Marino Autolinee, Itabus, FlixBus.
popular bus stations
Popular bus stations from Siena to Brindisi
Siena
Brindisi
The major bus station for departures in Siena is Siena, Stazione FS (Piazzale Carlo Rosselli). Find all the information you need to know about services, amenities and connections at Siena, Stazione FS (Piazzale Carlo Rosselli) for your trip from Siena to Brindisi.
Siena, Stazione FS (Piazzale Carlo Rosselli)
information
Siena, Siena/Viale Pietro Toselli
information
Siena, P.za Gramsc
information
The major bus station for arrivals in Brindisi is Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale). Find all the information you need to know about services, amenities and connections at Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) for your trip to Brindisi from Siena.
Most popular bus connections from Siena
More options for your journey from Siena to Brindisi
Here are some other resources that might have the information you need
Most popular buses to and from Brindisi and Siena
Most popular bus connections to Brindisi
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
