Journey information
Overview: Greenville, SC to Chicago, IL flight
Flights from Greenville, SC to Chicago, IL depart on average 27 times per day, taking around 2h 48m. Cheap flight tickets for this journey start at $220 (€178) but you can travel from only $124 (€101) by bus.
There are 1 flights per day. The earliest flight runs at 00:02, the last at 23:55. The fastest flight covers the 561 miles (903 km) distance in 2h 16m. February is the cheapest month to fly.
Distance 561 miles (903 km) |
Average flight duration 2h 48m |
Cheapest ticket price $220 (€178) |
Flights per day 27 |
Direct flights 1 |
Fastest flight 2h 16m |
Cheapest month February |
First flight 12:02 AM |
Last flight 11:55 PM |
Travel Information
Compare bus, train, and flight for Greenville, SC to Chicago, IL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $124. For those with little time consider booking a flight which can get you there in 2h 48m. The ticket price range depends on the travel mode: a bus costs an average of $124, and a flight costs an average of $220.
Distance: 561 miles (903 km)
Compare flight with
| Flight | Most popular Bus | Train |
|---|---|---|
$321 Average price | $188 Average price Cheapest | $265 Average price |
5h 48m Average total duration Fastest 2h 48m Onboard + 3h 0m Additional time* | 19h 10m Average total duration 18h 40m Onboard + 30m Additional time* | 33h 42m Average total duration 33h 12m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Greenville, SC to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Greenville, SC to Chicago, IL Flight
Find answers to the most common questions about traveling from Greenville, SC to Chicago, IL by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Chicago Air and Water Show, an exhilarating display of military and civilian aircraft performing daring maneuvers over Lake Michigan
- Lollapalooza, a massive music festival featuring top artists across multiple genres in Grant Park
- Chicago Gourmet, a premier culinary event celebrating the city's vibrant food scene with tastings, cooking demonstrations, and wine pairings.
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
- Memorial Day, the unofficial start of summer with vibrant outdoor activities and events
- Independence Day, spectacular fireworks and festive celebrations throughout the city
- Labor Day, a lively atmosphere with various festivals and pleasant weather.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
popular airports
Popular airports from Greenville, SC to Chicago, IL
- Free Wi-Fi available throughout the airport.
- Shops are located in all terminals, including duty-free and brands like Hudson and MAC Cosmetics.
- Parking available with options including hourly, daily, and economy lots, approximately 2.85€ ($3) per hour.
- Restaurants are located in all terminals, offering a variety of cuisines including American and intertiol. Top options include Tortas Frontera and Publican Tavern.
- Available outside the terminal.
- Elevators, ramps, toilets
- Available throughout the airport.
- Hotels such as Hilton Chicago O'Hare are located on airport grounds, with others like the Hyatt Regency nearby.
- Showers are available in some lounges, such as the United Club, but access may require a fee or membership.
- Lounges available, including United Club and American Airlines Admirals Club.
- Lost and Found located in terminal 1, near the baggage claim area.
- Car rental services are available at the Multi-Modal Facility, with companies like Hertz and Avis.
- CTA Blue Line, O'Hare Station, 45 minutes to city center
Most popular flights from Greenville, SC
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