The cheapest and fastest trains from Pisa to Lyon
Cheapest price
$199
Average price
$234
Fastest journey
9 h 7 m
Average duration
10 h 20 m
Trains per day
19
Distance
493 km
The best way to find a cheap train ticket from Pisa to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pisa to Lyon will cost around $234 if you buy it on the day, but the cheapest tickets can be found for only $199.
It's difficult to get from Pisa to Lyon without transferring at least once.
Regionale 2294 · Regionale Veloce TTPER 2462+
FRECCIAROSSA 1000 92965:48 AM14h44Pisa Centrale8:32 PMLyon Part Dieu$1991One-way2 transfers
Regionale 2294 · Regionale TRENORD 2362+
FRECCIAROSSA 1000 92965:48 AM14h44Pisa Centrale8:32 PMLyon Part Dieu$1991One-way2 transfers
Regionale 19332 · Regionale TTPER 19238 · Regionale Veloce TTPER 2466+
FRECCIAROSSA 1000 92967:02 AM13h30Pisa Centrale8:32 PMLyon Part Dieu$2011One-way3 transfers
Intercity 658+
FRECCIAROSSA 1000 92965:31 AM15h01Pisa Centrale8:32 PMLyon Part Dieu$2061One-way1 transfer
ETRUSCHI LINE 4014 · Regionale 17816 · Regionale Veloce TTPER 2470+
FRECCIAROSSA 1000 92967:30 AM13h02Pisa Centrale8:32 PMLyon Part Dieu$2081One-way3 transfers
TUSCANY LINE 4030+
FRECCIAROSSA 1000 9514+
FRECCIAROSSA 1000 929611:25 AM9h07Pisa Centrale8:32 PMLyon Part Dieu$2501One-way2 transfers
TUSCANY LINE 4028+
FRECCIAROSSA 1000 9416 · FRECCIAROSSA 8814+
FRECCIAROSSA 1000 929611:02 AM9h30Pisa Centrale8:32 PMLyon Part Dieu$2661One-way3 transfers
TUSCANY LINE 4026+
FRECCIAROSSA 9524+
FRECCIAROSSA 1000 929610:24 AM10h08Pisa Centrale8:32 PMLyon Part Dieu$2501One-way2 transfers
TUSCANY LINE 4020+
FRECCIAROSSA 9520+
FRECCIAROSSA 1000 92969:32 AM11h00Pisa Centrale8:32 PMLyon Part Dieu$2501One-way2 transfers
Intercity 666+
FRECCIAROSSA 1000 92968:37 AM11h55Pisa Centrale8:32 PMLyon Part Dieu$2141One-way1 transfer
Travel Information
Compare train, bus, and flight for Pisa to Lyon
Omio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $50. For those with little time consider booking a train which can get you there in 7h 51m. The ticket price range depends on the travel mode: a bus costs an average of $50, and a flight costs an average of $208.
Distance: 306 miles (493 km)
Compare train with
| Train | Most popular Bus | Flight |
|---|---|---|
$154 Average price | $88 Average price Cheapest | $739 Average price |
8h 21m Average total duration Fastest 7h 51m Onboard + 30m Additional time* | 11h 25m Average total duration 10h 55m Onboard + 30m Additional time* | 22h 4m Average total duration 19h 4m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Pisa to Lyon train times
The table below shows live departures for Pisa to Lyon trains for today, Wednesday, April 1. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:34 PM Pisa | 14h38 | 11:12 AM Lyon | 2 transfers | |
| Thursday, April 2 | |||||
Regionale 18250+ FRECCIAROSSA 9574+ FRECCIAROSSA 1000 9296 | 2:15 AM Pisa Centrale | 16h17 | 6:32 PM Lyon Part Dieu | 2 transfers | |
Intercity 658+ FRECCIAROSSA 1000 9296 | 3:31 AM Pisa Centrale | 15h01 | 6:32 PM Lyon Part Dieu | 1 transfer | |
Regionale 2294 · Regionale Veloce TTPER 2462+ FRECCIAROSSA 1000 9296 | 3:48 AM Pisa Centrale | 14h44 | 6:32 PM Lyon Part Dieu | 2 transfers | |
Regionale 2294 · Regionale TRENORD 2362+ FRECCIAROSSA 1000 9296 | 3:48 AM Pisa Centrale | 14h44 | 6:32 PM Lyon Part Dieu | 2 transfers | |
Tuscany Line 18260+ FRECCIAROSSA 1000 9508+ FRECCIAROSSA 1000 9296 | 4:24 AM Pisa Centrale | 14h08 | 6:32 PM Lyon Part Dieu | 2 transfers | |
Intercity 662+ FRECCIAROSSA 1000 9296 | 4:33 AM Pisa Centrale | 13h59 | 6:32 PM Lyon Part Dieu | 1 transfer | |
Regionale 19332 · Regionale TTPER 19238 · Regionale Veloce TTPER 2466+ FRECCIAROSSA 1000 9296 | 5:02 AM Pisa Centrale | 13h30 | 6:32 PM Lyon Part Dieu | 3 transfers | |
Regionale 19332 · Regionale TTPER 19238+ Intercity 580+ FRECCIAROSSA 1000 9296 | 5:02 AM Pisa Centrale | 13h30 | 6:32 PM Lyon Part Dieu | 3 transfers | |
ETRUSCHI LINE 4014+ FRECCIAROSSA 9512+ FRECCIAROSSA 1000 9296 | 5:30 AM Pisa Centrale | 13h02 | 6:32 PM Lyon Part Dieu | 2 transfers | |
ETRUSCHI LINE 4014 · Regionale 17816 · Regionale Veloce TTPER 2470+ FRECCIAROSSA 1000 9296 | 5:30 AM Pisa Centrale | 13h02 | 6:32 PM Lyon Part Dieu | 3 transfers | |
ETRUSCHI LINE 4014 · Regionale 17816+ Intercity 604+ FRECCIAROSSA 1000 9296 | 5:30 AM Pisa Centrale | 13h02 | 6:32 PM Lyon Part Dieu | 3 transfers | |
ETRUSCHI LINE 18270+ FRECCIAROSSA 1000 9406 · FRECCIAROSSA 1000 9616+ FRECCIAROSSA 1000 9296 | 5:47 AM Pisa Centrale | 12h45 | 6:32 PM Lyon Part Dieu | 3 transfers | |
Regionale 18272+ FRECCIAROSSA 9516+ FRECCIAROSSA 1000 9296 | 6:06 AM Pisa Centrale | 12h26 | 6:32 PM Lyon Part Dieu | 2 transfers | |
ETRUSCHI LINE 4016+ FRECCIAROSSA 9490 · FRECCIAROSSA 8810+ FRECCIAROSSA 1000 9296 | 6:32 AM Pisa Centrale | 12h00 | 6:32 PM Lyon Part Dieu | 3 transfers | |
Intercity 666+ FRECCIAROSSA 1000 9296 | 6:37 AM Pisa Centrale | 11h55 | 6:32 PM Lyon Part Dieu | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pisa to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Pisa to Lyon trains with Omio?
Why book with Omio vs Trenitalia?
- Compare with other providers: On Omio, you can not only buy tickets for Trenitalia, but also compare tickets for the likes of Regionale to find the best option for your trip from Pisa to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Trenitalia with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Pisa to Lyon.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Pisa to Lyon.
Journey information
Overview: Train from Pisa to Lyon
Trains from Pisa to Lyon run on average 1 times per day, taking around 7h 51m. Cheap train tickets for this journey start at $154 (€125) but you can travel from only $50 (€40) by bus.
The earliest train runs at 00:25, the last at 20:10. The fastest train covers the 306 miles (493 km) distance in 8h 23m.
Distance 306 miles (493 km) |
Average train duration 7h 51m |
Cheapest ticket price $154 (€125) |
Trains per day 1 |
Fastest train 8h 23m |
First train 12:25 AM |
Last train 8:10 PM |
Train companies: Trenitalia, Regionale from Pisa to Lyon trainsTrenitalia, Regionale trains will get you between Pisa and Lyon from $50 (€40). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Trenitalia
Regionale
FAQs: Trains from Pisa to Lyon
Find answers to the most common questions about traveling from Pisa to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Pisa to Lyon
- Mon - Sun: 06:00 - 20:30
- There is free Wi-Fi available at the McDonald's.
- There is a luggage storage office near the end of Platform 1.
- McDonald's
- Panetteria Binario 1
- Accessible facilities including barrier-free restrooms, elevators, ramps, and disabled parking. Sala Blu mobility assistance available from 07:45 to 22:30 with advanced one-hour notice.
- Hotel NH Pisa
- Hotel La Pace
- Hotel Maria
- Mon - Sun: 06:00 - 20:30
- Located just outside the station on Piazza Vittorio Emanuele II.
- Bus lines: 1
- Train lines: Pisamover (S2), FA, FB, IC, ICN, RV, R, EN
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Free unlimited WiFi.
- Luggage lockers are available daily from 06:15 to 23:15. They are located near the station's reception desk.
- Alto Café
- Paul
- Paul The Café
- Starbucks
- Exki
- Sushi Shop
- Carrefour
- Complimentary personalized care is available.
- Radisson Blu Hotel Lyon
- Mercure Lyon Center
- ibis Styles Lyon Center
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Located in the station's main hall.
- Metro lines: A, B, C, D
- Tram lines: T4, K240, T3, K100
- Bus lines: 2960, C2, C3, C6, C9
- Train lines: TGV, TGV Lyria, TGV INOUI, OUIGO, TER, Intercités, Eurostar, AVE
Most popular train connections from Pisa
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