Travel Information
Compare train, bus, and flight for Frankfurt am Main to Pisa
Omio recommends booking the flight as it is the most popular option from Frankfurt am Main to Pisa among Omio's users. If you are prioritising price take the bus with prices starting from $64. For those with little time consider booking a flight which can get you there in 2h 20m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.7 - 1.8kg. The ticket price range depends on the travel mode: a bus costs an average of $64, and a flight costs an average of $248.
Distance: 449 miles (723 km)
Compare flight with
Most popular Flight | Bus | Train |
|---|---|---|
$646 Average price | $103 Average price Cheapest | $309 Average price |
5h 20m Average total duration Fastest 2h 20m Onboard + 3h 0m Additional time* | 16h 46m Average total duration 16h 16m Onboard + 30m Additional time* | 18h 23m Average total duration 17h 53m Onboard + 30m Additional time* |
2.2 - 4.3kg CO2 emissions | 0.7 - 1.8kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Frankfurt am Main to Pisa
How to get from Frankfurt am Main to Pisa by train, bus or flight.
Our recommendation
The best way to travel from Frankfurt am Main to Pisa is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus8:00 PM17h20Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)1:20 PMPisa, Via delle Fiamme Gialle (Park Pietrasantina)$1361One-way2 transfers
Cheapest
FlixBus · FlixBus · FlixBus8:00 PM17h20Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)1:20 PMPisa, Via delle Fiamme Gialle (Park Pietrasantina)$1361One-way2 transfers
Fastest
EN88708:05 AM1h35Frankfurt am Main Airport9:40 AMPisa International Airport$4761One-way0 transfers
Other options
FlixTrain+
FlixBus · FlixBus4:30 PM20h50Frankfurt South station1:20 PMPisa, Via delle Fiamme Gialle (Park Pietrasantina)$1371One-way2 transfers
FlixBus · FlixBus9:20 PM20h00Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)5:20 PMPisa, Via delle Fiamme Gialle (Park Pietrasantina)$1361One-way1 transfer
FlixBus · FlixBus7:15 AM17h35Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)12:50 AMPisa, Via delle Fiamme Gialle (Park Pietrasantina)$1561One-way1 transfer
U22993+
Regionale 20727 · ETRUSCHI LINE 41403:40 PM8h35Frankfurt am Main Airport12:15 AMPisa Centrale$3411One-way2 transfers
KL1816+
KL265710:15 AM4h50Frankfurt am Main Airport3:05 PMPisa International Airport$3781One-way1 transfer
U22993+
Regionale 20721+
Intercity 5223:40 PM7h10Frankfurt am Main Airport10:50 PMPisa Centrale$3591One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Frankfurt am Main to Pisa
Travel to Pisa easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Frankfurt am Main to Pisa.

This is compared to other travel options from Frankfurt am Main to Pisa:
A bus is $184 (€150) less than a flight for this route with tickets for a flight from Frankfurt am Main to Pisa costing on average $248 (€202).
A bus is $198 (€161) less than a train for this route with tickets for a train from Frankfurt am Main to Pisa costing on average $261 (€213).
Other travel options to Pisa take longer:
Bus takes on average 17h 20m.
Train takes on average 13h 38m.
- Around 11 buses per day.
- Around 7 flights per day.
- Around 2 trains per day.
However, we recommend checking specific travel dates for your route between Frankfurt am Main and Pisa as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Pisa International Airport.
- Buses mostly depart from Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) and arrive in Pisa, Via delle Fiamme Gialle (Park Pietrasantina).
- Travel with Air Dolomiti, Transavia France to go to Pisa by flight.
- Travel with FlixBus to go to Pisa by bus.
- Travel with Deutsche Bahn to go to Pisa by train.
- 3 direct flights per day with Air Dolomiti.
Travelling from Frankfurt am Main to Pisa: related information
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