The cheapest and fastest buses from Lyon to Prague
Cheapest price
$110
Average price
$144
Fastest journey
14 h 50 m
Average duration
16 h 11 m
Buses per day
10
Distance
860 km
The best way to find a cheap bus ticket from Lyon to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon to Prague will cost around $144 if you buy it on the day, but the cheapest tickets can be found for only $110.
Of the 10 buses that leave Lyon for Prague on Thu, Apr 02, 7 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Apr 02 the direct buses cover the 860 km distance in an average of 16 h 11 m but if you time it right, some buses will get you there in just 14 h 50 m .
On Thu, Apr 02 the slowest buses will take 17 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus5:20 AM16h30Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)9:50 PMPraha, ÚAN Florenc$1101One-way0 transfers
FlixBus6:05 PM14h50Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)8:55 AMPraha, Na Knížecí$1231One-way0 transfers
FlixBus6:05 PM15h15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)9:20 AMPraha, ÚAN Florenc$1231One-way0 transfers
FlixBus · FlixBus5:20 AM17h35Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)10:55 PMPraha, Na Knížecí$1231One-way1 transfer
FlixBus · FlixBus6:05 PM17h15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)11:20 AMPrague, Central Train Station$1391One-way1 transfer
FlixBus6:05 PM14h50Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)8:55 AMPraha, Na Knížecí$1231One-way0 transfers
FlixBus6:05 PM15h15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)9:20 AMPraha, ÚAN Florenc$1231One-way0 transfers
FlixBus5:20 AM16h30Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)9:50 PMPraha, ÚAN Florenc$1101One-way0 transfers
FlixBus9:30 PM17h05Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)2:35 PMPrague, Central Train Station$1881One-way0 transfers
FlixBus · FlixBus6:05 PM17h15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)11:20 AMPrague, Central Train Station$1391One-way1 transfer
Travel Information
Compare bus, train, and flight for Lyon to Prague
Omio recommends booking the flight as it is the most popular option from Lyon to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $58. For those with little time consider booking a flight which can get you there in 2h 38m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $58, and a train costs an average of $279.
Distance: 534 miles (860 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$86 Average price Cheapest | $191 Average price | $313 Average price |
16h 49m Average total duration 16h 19m Onboard + 30m Additional time* | 5h 38m Average total duration Fastest 2h 38m Onboard + 3h 0m Additional time* | 12h 54m Average total duration 12h 24m Onboard + 30m Additional time* |
0.9 - 2.1kg CO2 emissions Lowest | 2.6 - 5.2kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Lyon to Prague Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:20AM | Arrival Time 08:20PM | Duration 20h00 | Departure days Mon, Tue, Sat | Cheapest price $140 |
Operator FlixBus | Departure Time 02:25AM | Arrival Time 10:55PM | Duration 20h30 | Departure days Wed | Cheapest price $110 |
Operator FlixBus | Departure Time 03:30AM | Arrival Time 10:15PM | Duration 18h45 | Departure days Tue, Fri, Sat | Cheapest price $94 |
Operator FlixBus | Departure Time 05:20AM | Arrival Time 10:55PM | Duration 17h35 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price $95 |
Operator BlaBlaCar Bus | Departure Time 12:00PM | Arrival Time 09:45AM | Duration 21h45 | Departure days Fri | Cheapest price $154 |
Operator FlixBus | Departure Time 12:15PM | Arrival Time 08:30AM | Duration 20h15 | Departure days Mon, Tue, Fri, Sat | Cheapest price $99 |
Operator Infobus | Departure Time 01:30PM | Arrival Time 02:00AM | Duration 12h30 | Departure days Mon | Cheapest price $209 |
Operator RegioJet a.s. | Departure Time 02:35PM | Arrival Time 06:25AM | Duration 15h50 | Departure days Sat | Cheapest price $107 |
Operator BlaBlaCar Bus | Departure Time 02:55PM | Arrival Time 09:45AM | Duration 18h50 | Departure days Mon | Cheapest price $112 |
Operator FlixBus | Departure Time 06:05PM | Arrival Time 08:55AM | Duration 14h50 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $100 |
Operator FlixBus | Departure Time 09:30PM | Arrival Time 02:35PM | Duration 17h05 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $101 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 04:10PM | Duration 18h10 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $92 |
Live departures
Lyon to Prague bus times
The table below shows live departures for Lyon to Prague buses for today, Wednesday, April 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 4:05 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 14h50 | 6:55 AM Praha, Na Knížecí | 0 transfersDirect | |
FlixBus | 4:05 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 15h15 | 7:20 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 4:05 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h15 | 9:20 AM Prague, Central Train Station | 1 transfer | |
FlixBus | 7:30 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h05 | 12:35 PM Prague, Central Train Station | 0 transfersDirect | |
FlixBus | 7:30 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h15 | 12:45 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus | 8:00 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 18h10 | 2:10 PM Praha, Černý Most | 0 transfersDirect | |
FlixBus | 8:00 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h25 | 1:25 PM Praha, ÚAN Florenc | 0 transfersDirect | |
| Thursday, April 2 | |||||
FlixBus | 3:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 16h30 | 7:50 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 3:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h35 | 8:55 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 3:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 19h05 | 10:25 PM Prague, Central Train Station | 1 transfer | |
Find all the dates and times for this journey
Compare prices and tickets Lyon to Prague by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Apr 01
Apr 02
Apr 03
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Apr 06
Apr 07
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Apr 09
Apr 10
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Apr 18
Apr 19
Apr 20
Apr 21
Why should you book Lyon to Prague buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of BlaBlaCar Bus to find the best option for your trip from Lyon to Prague.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Lyon to Prague.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of BlaBlaCar Bus to find the best option for your trip from Lyon to Prague.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Lyon to Prague.
Journey information
Overview: Bus from Lyon to Prague
Buses from Lyon to Prague run on average 12 times per day, taking around 16h 19m. Cheap bus tickets for this journey start at $58 (€47) but you can travel from only $54 (€44) by flight.
There are 6 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 534 miles (860 km) distance in 12h 30m.
Distance 534 miles (860 km) |
Average bus duration 16h 19m |
Cheapest ticket price $58 (€47) |
Buses per day 12 |
Direct buses 6 |
Fastest bus 12h 30m |
First bus 12:10 AM |
Last bus 11:50 PM |
Bus providers: FlixBus, BlaBlaCar Bus from Lyon to PragueYou can travel by bus between Lyon to Prague with FlixBus, BlaBlaCar Bus for as low as $54 (€44). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
BlaBlaCar Bus
FAQs: Bus from Lyon to Prague
Find answers to the most common questions about traveling from Lyon to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Prague Castle, a historic complex and the official office of the Czech president offering panoramic city views
- Charles Bridge, a 14th-century stone bridge adorned with statues and connecting the Old Town with Lesser Town
- Old Town Square, a vibrant historic square featuring the Astronomical Clock and Gothic churches
- St. Vitus Cathedral, a stunning Gothic cathedral known for its impressive architecture and stained glass windows
- The Jewish Quarter, a historic area with preserved synagogues and the Old Jewish Cemetery.
- Petrin Hill, a lush park providing panoramic views of the city and home to the Petrin Tower and Mirror Maze
- Explore the vibrant nightlife in the Vinohrady district, known for its trendy bars and cafes
- Take a boat cruise on the Vltava River to see Prague's landmarks from a different perspective
- Visit the National Museum to delve into Czech history and culture
- Enjoy a classical music concert in one of Prague's historic churches or concert halls.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Lyon to Prague
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Florenc (in the station)
- Bistro Florenc (0.2 km)
- Restaurace U Rozvařilů (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 133, 135, 175, 207 Metro: B, C
- 00:00-23:59
- Free Wi-Fi
- Czech Bistro (in the station)
- Fast Food Express (in the station)
- Bohemian Café (0.2 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 135, 175, 207 Metro: C Train: All major s
- Free Wi-Fi
- Café Na Knížecí (in the station)
- Bistro Praha (0.2 km)
- Restaurace U Knížete (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 137, 176, 191 Metro: B
Most popular bus connections from Lyon
More options for your journey from Lyon to Prague
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