The cheapest and fastest buses from Orlando, FL to Greenville, SC
Cheapest price
$75
Average price
$75
Fastest journey
17 h 5 m
Average duration
17 h 5 m
Buses per day
1
Distance
709 km
The best way to find a cheap bus ticket from Orlando, FL to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Greenville, SC will cost around $75 if you buy it on the day, but the cheapest tickets can be found for only $75.
Of the 1 buses that leave Orlando, FL for Greenville, SC on Sat, Apr 04, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Apr 04 the direct buses cover the 709 km distance in an average of 17 h 5 m but if you time it right, some buses will get you there in just 17 h 5 m .
On Sat, Apr 04 the slowest buses will take 17 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
7:00 PM17h05Orlando, FL12:05 PMGreenville, SC$751One-way0 transfers
7:00 PM17h05Orlando, FL12:05 PMGreenville, SC$751One-way0 transfers
Travel Information
Compare bus, train, and flight for Orlando, FL to Greenville, SC
Omio recommends booking the flight as it is the most popular option from Orlando, FL to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $75. For those with little time consider booking a flight which can get you there in 1h 50m. The ticket price range depends on the travel mode: a bus costs an average of $75, and a train costs an average of $139.
Distance: 440 miles (709 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$121 Average price Cheapest | $156 Average price | $194 Average price |
10h 20m Average total duration 9h 50m Onboard + 30m Additional time* | 4h 50m Average total duration Fastest 1h 50m Onboard + 3h 0m Additional time* | 29h 13m Average total duration 28h 43m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company |
Direct Options | Direct Options | Direct Options |
Live departures
Orlando, FL to Greenville, SC bus times
The table below shows live departures for Orlando, FL to Greenville, SC buses for today, Friday, April 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:00 PM Orlando, FL | 17h05 | 12:05 PM Greenville, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Orlando, FL to Greenville, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Apr 04
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Apr 10
Why should you book Orlando, FL to Greenville, SC buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Orlando, FL to Greenville, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Orlando, FL to Greenville, SC.
Journey information
Overview: Bus from Orlando, FL to Greenville, SC
Buses from Orlando, FL to Greenville, SC run on average 5 times per day, taking around 9h 50m. Cheap bus tickets for this journey start at $75 (€61) but you can travel from only $56 (€46) by flight.
The earliest bus runs at 04:45, the last at 23:40. The fastest bus covers the 440 miles (709 km) distance in 10h 25m.
Distance 440 miles (709 km) |
Average bus duration 9h 50m |
Cheapest ticket price $75 (€61) |
Buses per day 5 |
Fastest bus 10h 25m |
First bus 4:45 AM |
Last bus 11:40 PM |
Bus providers: Greyhound from Orlando, FL to Greenville, SCYou can travel by bus between Orlando, FL to Greenville, SC with Greyhound for as low as $56 (€46). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Orlando, FL to Greenville, SC
Find answers to the most common questions about traveling from Orlando, FL to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Orlando, FL to Greenville, SC
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