Travel Information
Compare bus, train, and flight for Prague to Mainz
Omio recommends booking the train as it is the most popular option from Prague to Mainz among Omio's users. If you are prioritising price take the bus with prices starting from $32. For those with little time consider booking a flight which can get you there in 1h 13m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $32, and a flight costs an average of $99.
Distance: 272 miles (439 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
$108 Average price | $44 Average price Cheapest | $156 Average price |
8h 12m Average total duration 7h 42m Onboard + 30m Additional time* | 7h 29m Average total duration 6h 59m Onboard + 30m Additional time* | 4h 13m Average total duration Fastest 1h 13m Onboard + 3h 0m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.6kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Prague to Mainz
How to get from Prague to Mainz by train, bus or flight.
Our recommendation
The best way to travel from Prague to Mainz is by taking a bus because it’s the best combination of price and speed.
FlixBus4:10 AM8h05Praha, Na Knížecí12:15 PMMainz, Binger Schlag (Kurzzeitparkplatz)$701One-way0 transfers
Cheapest
FlixBus4:10 AM8h05Praha, Na Knížecí12:15 PMMainz, Binger Schlag (Kurzzeitparkplatz)$701One-way0 transfers
Fastest
DE44088:50 AM1h00Prague Vaclav Havel Airport9:50 AMFrankfurt am Main Airport$1851One-way0 transfers
Other options
rj 384 · ICE 2510 · VIA 250226:31 AM9h48Prague hlavní nádraží4:19 PMMainz-Kastel station$1381One-way2 transfers
EC 358 · R 3568 · ICE 624 · S 351529:35 AM8h09Prague hlavní nádraží5:44 PMMainz-Kastel station$1921One-way3 transfers
EC 358 · R 3568 · ICE 624 · RB 245269:35 AM8h32Prague hlavní nádraží6:07 PMMainz-Bischofsheim station$1941One-way3 transfers
FlixBus3:50 AM8h25Prague, Central Train Station12:15 PMMainz, Binger Schlag (Kurzzeitparkplatz)$701One-way0 transfers
FlixBus · FlixBus7:55 AM11h35Praha, Na Knížecí7:30 PMMainz, Binger Schlag (Kurzzeitparkplatz)$1451One-way1 transfer
DE44065:00 PM1h00Prague Vaclav Havel Airport6:00 PMFrankfurt am Main Airport$2061One-way0 transfers
DE441012:00 PM1h00Prague Vaclav Havel Airport1:00 PMFrankfurt am Main Airport$2271One-way0 transfers
LO528 · LO37912:45 PM6h15Prague Vaclav Havel Airport7:00 PMFrankfurt am Main Airport$2141One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Apr 02
Apr 03
Apr 04
Apr 05
Apr 06
Apr 07
Apr 08
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Prague to Mainz
Travel to Mainz easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Mainz.

This is compared to other travel options from Prague to Mainz:
A bus is $10 (€8) less than a train for this route with tickets for a train from Prague to Mainz costing on average $42 (€34).
A bus is $67 (€54) less than a flight for this route with tickets for a flight from Prague to Mainz costing on average $99 (€80).
Other travel options to Mainz take longer:
Bus takes on average 6h 55m.
Train takes on average 7h 43m.
- Around 78 flights per day.
- Around 8 trains per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Prague and Mainz as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Prague Vaclav Havel Airport and arrive in Frankfurt am Main Airport.
- Trains mostly depart from Prague hlavní nádraží and arrive in Mainz Hbf.
- Buses mostly depart from Praha, ÚAN Florenc and arrive in Mainz, Binger Schlag (Kurzzeitparkplatz).
- Travel with FlixBus, BlaBlaCar to go to Mainz by bus.
- Travel with Lufthansa, Air Dolomiti to go to Mainz by flight.
- Travel with Deutsche Bahn to go to Mainz by train.
- 3 direct buses per day with FlixBus, BlaBlaCar.
- 9 direct flights per day with Lufthansa, Air Dolomiti.
Travelling from Prague to Mainz: related information
Here are some other resources that might have the information you need


