St. Louis, MO to San Francisco, CA bus with Greyhound

Wed, Apr 01
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2,000+ travel companies
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The cheapest and fastest buses from St. Louis, MO to San Francisco, CA

Showing times and prices for Apr 02

Cheapest price

$375

Average price

$375

Fastest journey

2 d 3 h 35 m

Average duration

2 d 3 h 35 m

Buses per day

1

Distance

2803 km

Cheap tickets

The best way to find a cheap bus ticket from St. Louis, MO to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from St. Louis, MO to San Francisco, CA will cost around $375 if you buy it on the day, but the cheapest tickets can be found for only $375.

Fast buses

Of the 1 buses that leave St. Louis, MO for San Francisco, CA on Thu, Apr 02, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Thu, Apr 02 the direct buses cover the 2803 km distance in an average of 2 d 3 h 35 m but if you time it right, some buses will get you there in just 2 d 3 h 35 m .

On Thu, Apr 02 the slowest buses will take 2 d 3 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • Greyhound
    10:30 PM51h35
    St. Louis, MO
    2:05 AMSan Francisco, CA
    $3751One-way
    0 transfers

Travel Information

Compare bus, train, and flight for St. Louis, MO to San Francisco, CA

Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $199. For those with little time consider booking a flight which can get you there in 8h 52m. The ticket price range depends on the travel mode: a bus costs an average of $199, and a train costs an average of $218.

Distance: 1741 miles (2803 km)

Compare bus with

Bus
Most popular
Train
Flight

$372

Average price

Cheapest

$736

Average price

$440

Average price

51h 18m

Average total duration

50h 48m

Onboard

+

30m

Additional time*

59h 0m

Average total duration

58h 30m

Onboard

+

30m

Additional time*

11h 52m

Average total duration

Fastest

8h 52m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Direct Options

St. Louis, MO to San Francisco, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
08:40AM
Arrival Time
07:15AM
Duration
48h35
Departure days
Mon
Cheapest price
$295
Operator
Greyhound
Departure Time
09:10AM
Arrival Time
05:35PM
Duration
58h25
Departure days
Mon
Cheapest price
$273
Operator
Greyhound
Departure Time
04:30PM
Arrival Time
05:35PM
Duration
51h05
Departure days
Mon
Cheapest price
$274

Compare prices and tickets St. Louis, MO to San Francisco, CA by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Thu
Apr 02
Fri
Apr 03
Sat
Apr 04
Sun
Apr 05
Mon
Apr 06
Tue
Apr 07
Wed
Apr 08

Why should you book St. Louis, MO to San Francisco, CA buses with Omio?

Greyhound operates all buses services from St. Louis, MO to San Francisco, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Francisco, CA.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from St. Louis, MO to San Francisco, CA.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from St. Louis, MO to San Francisco, CA.

Journey information

Overview: Bus from St. Louis, MO to San Francisco, CA

USAUSA
USAUSA
Icon of bus

Buses from St. Louis, MO to San Francisco, CA run on average 9 times per day, taking around 50h 48m. Cheap bus tickets for this journey start at $199 (€161) if you book in advance.

The earliest bus runs at 01:20, the last at 23:25. The fastest bus covers the 1741 miles (2803 km) distance in 45h 55m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
1741 miles (2803 km)
Average bus duration
50h 48m
Cheapest ticket price
$199 (€161)
Buses per day
9
Fastest bus
45h 55m
First bus
1:20 AM
Last bus
11:25 PM
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from St. Louis, MO to San Francisco, CAYou can travel by bus between St. Louis, MO to San Francisco, CA with Greyhound for as low as $199 (€161). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
45h 55m
Cheapest Price
$199 (€161)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from St. Louis, MO to San Francisco, CA

Find answers to the most common questions about traveling from St. Louis, MO to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from St. Louis, MO to San Francisco, CA can start from as little as $199 (€161) when you book in advance. The average bus ticket price for St. Louis, MO to San Francisco, CA is $372 (€302) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to San Francisco, CA is 45h 55m to travel the 1741 miles (2803 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to San Francisco, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to San Francisco, CA leaves at 11:25 PM.
There are 9 buses a day from St. Louis, MO to San Francisco, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to San Francisco, CA, you can count on Greyhound for the best way to get you to San Francisco, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and San Francisco, CA and compare the amenities they offer before buying a bus ticket.
A trip to San Francisco, CA from St. Louis, MO is worth doing but not as a day trip with a journey time of 45h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to San Francisco, CA is October.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Francisco, CA including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to San Francisco, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to San Francisco, CA for bus company Greyhound.
Some of the most interesting sights to explore in San Francisco, CA are:
  • Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
  • Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
  • Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
  • Golden Gate Park, a large urban park with gardens, museums, and recreational activities
  • Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
The best things to do in San Francisco, CA include:
  • Ride a cable car through the steep streets of San Francisco for a classic city experience
  • Explore the vibrant murals and street art in the Mission District
  • Visit the Exploratorium, an interactive science museum perfect for all ages
  • Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
  • Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
Whether you can cancel your bus ticket from St. Louis, MO to San Francisco, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to San Francisco, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to San Francisco, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to San Francisco, CA:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to San Francisco, CA.
You can reserve your seat on the bus from St. Louis, MO to San Francisco, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to San Francisco, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to San Francisco, CA with the following bus company: Greyhound.
Since neither St. Louis, MO nor San Francisco, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Francisco, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Francisco, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like Fisherman's Wharf and Union Square. Common scams include distraction techniques used by groups to steal wallets and fake charity solicitations. It's advisable to avoid poorly lit or isolated areas at night and be wary of unofficial taxi services to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from St. Louis, MO to San Francisco, CA

St. Louis
San Francisco
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to San Francisco.
St. Louis, S 15th St (Civic center)
information
St. Louis, Lambert International Airport
information

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