St. Louis, MO to Durham, NC bus

Thu, Apr 02
+ Add return
FlixBus
Alsa
BlaBlaCar Bus
Costa Verde
Rede Expressos
2,000+ travel companies
FlixBus
Alsa
BlaBlaCar Bus
Costa Verde
Rede Expressos
2,000+ travel companies
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The cheapest and fastest buses from St. Louis, MO to Durham, NC

Showing times and prices for Apr 02

Cheapest price

$174

Average price

$174

Fastest journey

21 h 40 m

Average duration

21 h 40 m

Buses per day

1

Distance

1041 km

Cheap tickets

The best way to find a cheap bus ticket from St. Louis, MO to Durham, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from St. Louis, MO to Durham, NC will cost around $174 if you buy it on the day, but the cheapest tickets can be found for only $174.

Fast buses

It's difficult to get from St. Louis, MO to Durham, NC without transferring at least once.

  • Flixbus USA
    11:30 PM21h40
    St. Louis, MO
    9:10 PMDurham, NC
    $1741One-way
    1 transfer

Live departures

St. Louis, MO to Durham, NC bus times

The table below shows live departures for St. Louis, MO to Durham, NC buses for today, Wednesday, April 1. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
meinfernbus_flixbus11:30 PM St. Louis, MO
21h40
9:10 PM Durham, NC1 transfer

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets St. Louis, MO to Durham, NC by train

Compare train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Thu
Apr 02
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Apr 03
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Apr 04
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Apr 05
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Apr 06
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Apr 07
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Apr 08

Journey information

Overview: Bus from St. Louis, MO to Durham, NC

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Icon of bus

Take a bus from St. Louis, MO to Durham, NC and enjoy the approximately 646 miles (1041 km) long journey. Find schedules and pricing options for a convenient and affordable trip.

The earliest bus runs at 01:00, the last at 23:30.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $432 (€350)
Distance
646 miles (1041 km)
Buses per day
4
First bus
1:00 AM
Last bus
11:30 PM
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $432 (€350)

FAQs: Bus from St. Louis, MO to Durham, NC

Find answers to the most common questions about traveling from St. Louis, MO to Durham, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.

FAQs
The earliest bus from St. Louis, MO to Durham, NC leaves at 1:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Durham, NC leaves at 11:30 PM.
The cheapest month for a bus from St. Louis, MO to Durham, NC is September.
Yes, you can take a train between St. Louis, MO and Durham, NC.
No, the bus from St. Louis, MO to Durham, NC has no accessibility options.
No, there are no bathrooms on board the bus from St. Louis, MO to Durham, NC.
No, bikes are not allowed on board the bus from St. Louis, MO to Durham, NC.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from St. Louis, MO to Durham, NC.
No, luggage for the bus from St. Louis, MO to Durham, NC needs to be booked in addition.
No, there are no additional luggage options for the bus from St. Louis, MO to Durham, NC.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to Durham, NC.
No, there are no USB plugs on board the bus from St. Louis, MO to Durham, NC.
No, there is no WiFi on board the bus from St. Louis, MO to Durham, NC.
Since neither St. Louis, MO nor Durham, NC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to Durham, NC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Durham, NC, travelers should stay alert to common urban safety concerns such as petty theft, especially in crowded areas and public transit. Scams may include overcharging by unofficial taxi services or ride-share drivers, so using reputable transportation apps is advised. It's also important to avoid isolated areas after dark and keep personal belongings secure to reduce risk.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from St. Louis, MO to Durham, NC

St. Louis
Durham
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to Durham.
St. Louis, S 15th St (Civic center)
information

More options for your journey from St. Louis, MO to Durham, NC

Here are some other resources that might have the information you need

Tickets and more information for coaches to St. Louis, MO
Tickets and more information for coaches to Durham, NC

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