Travel Information
Compare train, bus, and flight for Pisa to Lyon
Omio recommends booking the bus as it is the most popular option from Pisa to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $50. For those with little time consider booking a train which can get you there in 7h 51m. The ticket price range depends on the travel mode: a bus costs an average of $50, and a train costs an average of $153.
Distance: 306 miles (493 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$87 Average price Cheapest | $153 Average price |
11h 25m Average total duration 10h 55m Onboard + 30m Additional time* | 8h 21m Average total duration Fastest 7h 51m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Travel optionsfrom Pisa to Lyon
How to get from Pisa to Lyon by train, bus or flight.
Our recommendation
The best way to travel from Pisa to Lyon is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus6:25 AM11h45Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:10 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1291One-way1 transfer
Cheapest
FlixBus · FlixBus6:25 AM11h45Pisa, Via delle Fiamme Gialle (Park Pietrasantina)6:10 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1291One-way1 transfer
Fastest
KL2656+
KL14353:25 PM7h25Pisa International Airport10:50 PMLyon Saint Exupery Airport$10921One-way1 transfer
Other options
Regionale 2294 · Regionale TRENORD 2362+
FRECCIAROSSA 1000 92965:48 AM14h44Pisa Centrale8:32 PMLyon Part Dieu$1981One-way2 transfers
Regionale 2294 · Regionale Veloce TTPER 2462+
FRECCIAROSSA 1000 92965:48 AM14h44Pisa Centrale8:32 PMLyon Part Dieu$1981One-way2 transfers
Intercity 662+
FRECCIAROSSA 1000 92966:33 AM13h59Pisa Centrale8:32 PMLyon Part Dieu$2131One-way1 transfer
FlixBus · FlixBus7:15 AM15h25Pisa, Via delle Fiamme Gialle (Park Pietrasantina)10:40 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1311One-way1 transfer
FlixBus · FlixBus1:50 PM14h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)3:55 AMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1451One-way1 transfer
FlixBus · FlixBus9:40 AM14h05Pisa, Via delle Fiamme Gialle (Park Pietrasantina)11:45 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1621One-way1 transfer
BA617 · BA3568:55 PM13h30Pisa International Airport10:25 AMLyon Saint Exupery Airport$9721One-way1 transfer
KL2656+
KL14273:25 PM18h00Pisa International Airport9:25 AMLyon Saint Exupery Airport$10921One-way1 transfer
KL2656+
KL14313:25 PM22h00Pisa International Airport1:25 PMLyon Saint Exupery Airport$10921One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Pisa to Lyon
Travel to Lyon easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Pisa to Lyon.

This is compared to other travel options from Pisa to Lyon:
A bus is $104 (€85) less than a train for this route with tickets for a train from Pisa to Lyon costing on average $153 (€125).
A bus is $158 (€129) less than a flight for this route with tickets for a flight from Pisa to Lyon costing on average $208 (€169).
Other travel options to Lyon take longer:
Bus takes on average 11h 45m.
Flight takes on average 6h 30m.
- Around 5 flights per day.
- Around 5 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Pisa and Lyon as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Pisa International Airport and arrive in Lyon Saint Exupery Airport.
- Trains mostly depart from Pisa Centrale and arrive in Lyon Part Dieu.
- Buses mostly depart from Pisa, Via delle Fiamme Gialle (Park Pietrasantina) and arrive in Lyon, Perrache Bus Station.
- Travel with FlixBus, BlaBlaCar, Lirosi Linee to go to Lyon by bus.
- Travel with Trenitalia, Regionale to go to Lyon by train.
- 0 direct buses per day with BlaBlaCar.
Travelling from Pisa to Lyon: related information
Here are some other resources that might have the information you need
