Travel Information
Compare train and bus for Prague to Karlsruhe
Omio recommends booking the train as it is the most popular option from Prague to Karlsruhe among Omio's users. If you are prioritising price take the bus with prices starting from $34. For those with little time consider booking a bus which can get you there in 6h 40m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $34, and a train costs an average of $32.
Distance: 280 miles (452 km)
Compare train with
Most popular Train | Bus |
|---|---|
$82 Average price | $50 Average price Cheapest |
9h 42m Average total duration 9h 12m Onboard + 30m Additional time* | 7h 10m Average total duration Fastest 6h 40m Onboard + 30m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.1kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Prague to Karlsruhe
How to get from Prague to Karlsruhe by train, bus or flight.
Our recommendation
The best way to travel from Prague to Karlsruhe is by taking a bus because it’s the best combination of price and speed.
FlixBus6:40 AM8h35Praha, ÚAN Florenc3:15 PMKarlsruhe Hbf$721One-way0 transfers
Cheapest
FlixBus6:40 AM8h35Praha, ÚAN Florenc3:15 PMKarlsruhe Hbf$721One-way0 transfers
Fastest
DE4406+
ICE 2035:00 PM3h59Prague Vaclav Havel Airport8:59 PMKarlsruhe Hbf$2691One-way1 transfer
Other options
EX 356 · 3574 · IC 206611:35 AM9h19Prague hlavní nádraží8:54 PMKarlsruhe Hbf$1261One-way2 transfers
EX 358 · 3568 · 88618 · ICE 10649:35 AM8h46Prague hlavní nádraží6:21 PMKarlsruhe Hbf$1351One-way3 transfers
EX 358 · 3570 · IC 20689:35 AM9h16Prague hlavní nádraží6:51 PMKarlsruhe Hbf$1541One-way2 transfers
FlixBus3:10 PM8h40Praha, ÚAN Florenc11:50 PMKarlsruhe Hbf$721One-way0 transfers
FlixBus2:30 PM9h20Praha, Černý Most11:50 PMKarlsruhe Hbf$721One-way0 transfers
FlixBus · FlixBus10:55 AM10h25Praha, Na Knížecí9:20 PMKarlsruhe Hbf$771One-way1 transfer
DE4408+
ICE 517 · ICE 3718:50 AM5h09Prague Vaclav Havel Airport1:59 PMKarlsruhe Hbf$2481One-way2 transfers
DE4408+
ICE 1098:50 AM8h09Prague Vaclav Havel Airport4:59 PMKarlsruhe Hbf$2481One-way1 transfer
DE4408+
ICE 1078:50 AM6h09Prague Vaclav Havel Airport2:59 PMKarlsruhe Hbf$2571One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Prague to Karlsruhe
Travel to Karlsruhe easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Karlsruhe.

This is compared to other travel options from Prague to Karlsruhe:
A train is $2 (€2) less than a bus for this route with tickets for a bus from Prague to Karlsruhe costing on average $34 (€28).
Other travel options to Karlsruhe take longer:
Train takes on average 8h 17m.
- Around 20 buses per day.
- Around 10 trains per day.
However, we recommend checking specific travel dates for your route between Prague and Karlsruhe as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Prague hlavní nádraží and arrive in Karlsruhe Hbf.
- Buses mostly depart from Praha, ÚAN Florenc and arrive in Karlsruhe Hbf.
- Travel with FlixBus, BlaBlaCar, Infobus to go to Karlsruhe by bus.
- Travel with Deutsche Bahn, České dráhy, ÖBB | Euro City (EC) to go to Karlsruhe by train.
- 8 direct buses per day with FlixBus, BlaBlaCar.
- 0 direct trains per day with ÖBB | Euro City (EC).
Travelling from Prague to Karlsruhe: related information
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